OPC-3 Isotonix – Antioxidant Supplement – Pycnogenol, Grape Seed Extracts, Bilberry, Red Wine & Pine Bark Extracts – for Heart & Circulatory Support – Isotonic, Vegan, Gluten Free – 90 Servings

Product description

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Customer Reviews

4.6 out of 5 stars 1,172

4.6 out of 5 stars 396

4.5 out of 5 stars 430

4.8 out of 5 stars 12

4.6 out of 5 stars 103

4.5 out of 5 stars 204

Price

$82.45$82.45 $84.70$84.70 $33.22$33.22 $99.95$99.95 $40.95$40.95 $36.19$36.19

Primary Benefit
Antioxidant & Heart Support Daily Multivitamin + OPC-3 Bone & Muscle Health Energy, Hydration, Immunity Antioxidant & Heart Support Digestive & Nutrient Absorption

Isotonic Formula

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Contains OPC-3 (Pycnogenol)

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Servings per Container
90 30 90 30 20 40

Gluten-Free / Non-GMO

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Freedman, J., et al. Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release. Circulation 103:2792-8, 2001.Frémont, L. Biological effects of resveratrol. Life Sciences 66: 663-673, 2000.Gulati, O. Pycnogenol(R) in venous disorders: a review. European Bulletin of Drug Research 7: 1-13, 1999.Hosseini, S., et al. Pycnogenol(R) in the management of asthma. Journal of Medicinal Food 4: 201-209, 2001. HHHhKohama, T., et al. The treatment of gynecological disorders with Pycnogenol(R). European Bulletin of Drug Research 7: 30-32, 1999.Kohama, T., et al. Analgesic efficacy of French maritime pine bark extract in dysmenorrhea. Journal of Reproductive Medicine 49: 828-32, 2004.Liu, X., et al. Antidiabetic effect of Pycnogenol French maritime pine bark extract in patients with diabetes type II. Life Sci 75:2505-13, 2004.Liu, X., et al. French maritime pine bark extract pycnogenol dose-dependently lowers glucose in type 2 diabetic patients. Diabetes Care 27: 839, 2004.Manna, S., et al. Resveratrol suppresses TNF-Induced activation of nuclear transcription factors NF-kB, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation. The Journal of Immunology 164: 6509-19, 2000.Maritim, A., et al. Effects of pycnogenol treatment on oxidative stress in streptozotocin-induced diabetic rats. J Biochem Mol Toxicol 17:193-9, 2003.Miyagi, Y., et al. Inhibition of human low-density lipoprotein oxidation by flavonoids in red wine and grape juice. Am J Cardiol 0:1627-31, 1997.Monograph. Vaccinium myrtillus (bilberry). Altern Med Rev 6:500-4, 2001.Murias M., et al. Resveratrol analogues as selective cyclooxygenase-2 inhibitors: synthesis and structure-activity relationship. , 2004.Nuttall SL, Kendall MJ, Bombardelli E, Morazzoni P. An evaluation of the antioxidant activity of a standardized grape seed extract, Leucoselect. J Clin Pharm Ther 23: 385-89, 1998.Packer, L., et al. Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, pycnogenol. Free Radic Biol Med 27:704-24, 1999. Review.Rohdewald, P. A review of the French maritime pine bark extract (Pycnogenol(R)), a herbal medication with a diverse clinical pharmacology. Int J Clin Pharmacol Ther 40:158-68, 2002. Review.Rohdewald, P. Pycnogenol(R). In “Flavonoids in Health and Disease”. Ed. Catherine Rice-Evans and Lester Packer. New York: Marcel Dekker, Inc., 1998. 405-19.Saito, M., et al. Antiulcer activity of grape seed extract and procyanidins. J Agric Food Chem 46: 1460-4, 1998.Schönlau, F., et al. Pycnogenol(R) for diabetic retinopathy. International Ophthalmology 24: 161-171, 2002.Schönlau, F., et al. The cosmeceutical Pycnogenol(R). J Appl Cosmetology 20: 241-6, 2002.Segger, D. and Schönlau, F. Supplementation with Evelle(R) improves skin smoothness and elasticity in a double blind, placebo-controlled study with 62 women. Journal of Dermatological Treatment 15:222-26, 2004.Shi, J., et al. Polyphenolics in grape seeds-biochemistry and functionality. J Med Food 6:291-9, 2003. Review.Sharma, S., et al. Pycnogenol(R) inhibits the release of histamine from mast cells. Phytotherapy Research 17: 66-69, 2003.Spadea, L., et al. Treatment of vascular retinopathies with Pycnogenol(R). Phytotherapy Research 15: 219-23, 2001.Stein, J., et al. Purple grape juice improves endothelial function and reduces the susceptibility of LDL cholesterol to oxidation in patients with coronary artery disease. Circulation 100:1050-5, 1999.Takada, Y., et al. Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-kappaB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation. Oncogene 23: 9247-58, 2004.Ueda, T., et al. Preventative effect of natural and synthetic antioxidants on lipid peroxidation in the mammalian eye. Ophthalmic Res 28: 184-92, 1996.

(FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease).

Is Discontinued By Manufacturer ‏ : ‎ No
Product Dimensions ‏ : ‎ 3.4 x 2.5 x 6.6 inches; 0.2 ounces
Item model number ‏ : ‎ AX-AY-ABHI-101410
Date First Available ‏ : ‎ March 11, 2015
Manufacturer ‏ : ‎ Market America
ASIN ‏ : ‎ B01GXUPDE8
Best Sellers Rank: #31,823 in Health & Household (See Top 100 in Health & Household) #66 in Antioxidant Combination Nutritional Supplements
Customer Reviews: 4.6 4.6 out of 5 stars 1,172 ratings var dpAcrHasRegisteredArcLinkClickAction; P.when(‘A’, ‘ready’).execute(function(A) { if (dpAcrHasRegisteredArcLinkClickAction !== true) { dpAcrHasRegisteredArcLinkClickAction = true; A.declarative( ‘acrLink-click-metrics’, ‘click’, { “allowLinkDefault”: true }, function (event) { if (window.ue) { ue.count(“acrLinkClickCount”, (ue.count(“acrLinkClickCount”) || 0) + 1); } } ); } }); P.when(‘A’, ‘cf’).execute(function(A) { A.declarative(‘acrStarsLink-click-metrics’, ‘click’, { “allowLinkDefault” : true }, function(event){ if(window.ue) { ue.count(“acrStarsLinkWithPopoverClickCount”, (ue.count(“acrStarsLinkWithPopoverClickCount”) || 0) + 1); } }); });

Powerful Antioxidant Supplement – Features Pycnogenol, grape seed extract, pine bark extract, red wine extract, bilberry, and citrus bioflavonoids for comprehensive antioxidant support.
Supports Healthy Circulation & Cardiovascular Wellness – Helps maintain healthy blood flow and promotes normal blood vessel dilation, contributing to overall heart health.
Helps Maintain Healthy Cholesterol Levels – Grape seed extract assists in maintaining healthy cholesterol for balanced cardiovascular support.
Promotes Energy & Vitality – Formulated to support healthy oxygen delivery to muscles and vital organs for daily energy and performance.
Provides 95% Nutrient Absorption – Isotonic delivery system ensures rapid and efficient absorption of key nutrients for maximum effect.
Supports Healthy Vision – Bilberry extract and red wine extract provide antioxidant protection supporting healthy eyesight and normal circulation.
Vegan, Gluten Free & Non-GMO – Made with no detectable GMOs, dairy, or gluten. Produced under Good Manufacturing Practices for quality assurance.
Easy Daily Routine – Mix one capful (3.3g) with 2 fl. oz. of water and enjoy once daily on an empty stomach for best absorption.